Okay, so, Afflictions is in need of an overhaul, I think we can agree - it only really covers combat, and that, not very well.
Let's start with the basic definition - To me, it ought to be re-written to something like "An Affliction is a negative effect on a character with a duration. They often trade immediate effects for more power over a duration, to improve a situation, or are used before combat to weaken an opponent that must be fought. They can also be used to limit or negate a threat, or alter a situation in favor of the players, if used in a clever fashion."
Combat Afflictions: The most common forms of "In Combat Afflictions" are: poison, burning, shock, paralysis, nausea, frozen, and blind.
Other discussed Afflictions: various stat eaters, psyche damage, sensory damage, madness infliction (predisposition, resistance reduction, immediate checks, and actual forced madness), temporary or permanent, various diseases, Enervate (stamina recovery debuff), various other debuffs to found stats, like stability, SAs and skills.